CSF1 and neoplasm: In mice bearing chemoresistant MCF-7 breast cancer xenograft treatment with combined chemotherapy (CMF—cyclophosphamide, methotrexate, 5-fluorouracil) and anti-CSF-1 Fab [murinized, polyethylene glycol-linked antigen-binding fragment (Fab) against mouse (host) CSF-1] reversed chemoresistance of MCF-7 xenografts, reduced angiogenesis, macrophage recruitment, suppressed tumor growth, down-regulated expression of the chemoresistance genes, and improved survival rates (101).