RNA-seq analysis of 199 tumor tissues from the same Swedish cohort showed the positive correlation of MARCO gene expression with the expression of genes associated with immunosuppressive TAMs (CD163, CD204, IL4R, CHIA, TGFB1, and IL10), genes of regulatory T-cells (FOXP3, TGFB1, IL10, EBI3, PDCD1, and CTLA4), genes of exhausted T-cells (PDCD1, CTLA4, TIGIT, BTLA, HAVCR2, and LAG3), genes of cytotoxic T-cells (CD8A, PRF1, GZMA, and GZMB) and genes of immune checkpoint molecules PD-L1, VISTA, PD-1, and CTLA4 (179). The gene discussed is CTLA4; the disease is neoplasm.