Thus, in vivo in MMTV-PyMT (PyMT) tumor-bearing mice, treatment with paclitaxel (PTX) in combination with CSF1 and cKIT receptor tyrosine kinases inhibitor (PLX3397) but not with PTX alone resulted in a significant reduction in CD31+ vessel density, reduced pulmonary metastases, and activation of cytotoxic T cell response (72). This evidence concerns the gene CSF1 and neoplasm.