PCOLCE2 and ovarian cancer: Transcriptomic analysis (RNA-seq) of TAMs isolated from 18 ascites of ovarian cancer patients (Germany cohort, serouse, and clear cell carcinoma) revealed two signatures of expressing genes: signature A, characterized by the hyperexpression of pro-tumor markers (CD163, PCOLCE2, IL6) related to ECM remodeling and signature B with low expression of pro-tumorigenic and immunosuppressive markers and an upregulation of genes linked to interferon signaling (225).