Thus, the results of meta-analysis of 16 studies (Chinese, Finnish, Swedish, Korean, UK, and USA cohorts) with a total 4,541 BC patients indicated that breast cancer with high TAM infiltration was significantly correlated with characteristics of aggressive biological behavior, such as tumor size, histological grade, ER and PR status, basal phenotype, vascular invasion (68). This evidence concerns the gene ESR1 and breast cancer.