In vitro in co-culture of THP-1 macrophages and A2780 cancer cells, cisplatin downregulated expression of CD274, IL-6 and HLA-DRA without inducing M2-type markers in M1-type macrophages, while doxorubicin caused the decrease in HLA-DRA and increase in CD206 (231). The gene discussed is IL6; the disease is cancer.