Chemotherapy with paclitaxel or carboplatin may generate debris in ID8 ovarian cancer cells which triggers macrophage production of the proinflammatory cytokines TNF-α, MIP-2/CXCL2, MIP-1β/CCL4, CCL2/MCP-1, as well as sICAM-1/CD54 and G-CSF (236). The gene discussed is CCL4; the disease is ovarian cancer.