Targeted sequencing of a panel of 1,021 genes was done with DNA purified from the tumor tissue.<h4>Results</h4>Two previously unreported germline mutations in the DDR pathway, <i>BRCA2</i> (c.8474_8487delCATACCCTATACAG, p.A2825Vfs*15) and <i>PALB2</i> (c.472delC, p.Q158Rfs*19) were identified in a patient with metastatic PCa. This evidence concerns the gene BRCA2 and neoplasm.