TP53 and central nervous system cancer: In our study, we illustrated that low ATRX is associated with poor characteristics (recurrence, 1p/19q non-codeletion) and prognosis of glioma patients in CGGA datasets; however, ATRX may function differently combined with other pathological characteristics such as TP53, IDH1, and TERT (17, 18); further research is still needed.