Abnormal expression of lncRNA has also been used as a prognostic marker for many tumors, such as lncRNA-AFAP1-AS1 (23), lncRNA-UCA1 (24), etc. Liu et al (16) found that the novel lnRNA-HOST2 can affect the transcription process upstream of the miR-let-7b promoter and significantly promote the expression of downstream proteins, thus enhancing the proliferation and migration of PCa cells. This evidence concerns the gene AFAP1 and posterior cortical atrophy.