BAX and cancer: In a study investigating breast cancer, Moghtaderi et al. reported that the combination of the polysaccharide arabinogalactan and curcumin noticeably reduced cancer cell growth to promote the apoptosis of human breast cancer cells, and observably up-regulated the Bax/Bcl-2 ratio and expression of cleaved-caspase3 in MDA-MB-231 human breast cancer cells (26).