By analyzing normal esophageal mucosa, esophageal dysplasia, and ESCC, Guo et al. also found clear evidence of accumulated methylation events during ESCC progression, which included accumulation of promoter region methylation of genes MGMT, p16, BRCA1, MLH1, CDH1, RARβ2, DAPK, and APC (28, 71). Here, APC is linked to esophageal squamous cell carcinoma.