Indeed, several studies have demonstrated that TSG expression could be restored after treatment of cells with demethylating agents, and DNMT inhibitors, such as azacytidine and decitabine, are currently under preclinical and clinical investigations in various cancer types (e.g., ClinicalTrials.gov Identifier: NCT01193517, NCT03666559, and NCT04187703) (90–93). Here, DNMT1 is linked to cancer.