Moreover, in hepatocellular carcinoma, PD-L2 expression was unfavorable both for OS and DFS/PFS, but, in esophageal cancer, high PD-L2 expression implied a trend toward favorable prognosis, suggesting that PD-L2 has different effects on immune suppression among different cancer types (17). The gene discussed is PDCD1LG2; the disease is hepatocellular carcinoma.