KCNQ1OT1 and medical procedure: For example, KCNQ1OT1 has been reported to promote drug resistance of CRC cells by sponging miR-34a (49) or miR-760 (50), and contribute to cell proliferation, migration and EMT formation in CRC through regulating miR-217/ZEB1 axis (51); SNHG1 could act as decoy of miR-137 (52), miR-497 (53), miR-195-5p (53), miR-154-5p (54) and miR-145 (55) to weaken their suppressive effect on target genes, thereby facilitating colorectal tumorigenesis.