Strikingly, MALAT1 and KCNQ1OT1 were significantly associated with overall survival (OS) times of colon cancer patients (Figure 4D), while lncRNA biomarkers identified in rectal M0/N or M1/N groups were not related to patients prognosis, suggesting they may participate in the regulation of prognosis through other mechanisms. The gene discussed is KCNQ1OT1; the disease is malignant colon neoplasm.