TP53 and malignant colon neoplasm: As shown in Figures 2B, C, DEmRNAs identified in colon M0/N and M1/N groups were significantly enriched in diverse critical biological pathways, e.g. “cell cycle”, “protein digestion and absorption”, “p53 signaling pathway” and “PPAR signaling pathway”, revealing their essential roles in tumorigenesis of colon cancer.