Moreover, both of the results from CCLE (Cancer Cell Line Encyclopedia) database and qRT-PCR analysis showed that KCNQ1OT1 and SNHG1 had significantly higher expression level in CRC cell lines with high metastatic potential (e.g. SW620) than that with low metastatic potential (e.g. SW480) (Figures 5D, E), implying their roles in promoting CRC metastasis. This evidence concerns the gene SNHG1 and cancer.