As shown in the proposed mechanism, KCNQ1OT1 may regulate the initiation of colon cancer by sponging miR-484 to derepress its inhibiting effect on ANKRD36 that related to prognosis, accelerate the initiation of rectal cancer by acting as a miR-132-3p-mediated ceRNA of OGT, while promote the metastasis of colon and rectal cancers through miR-181a-5p-mediated ceRNA regulatory relationship (Figure 8B). Here, KCNQ1OT1 is linked to rectal cancer.