Although SNHG1 or KCNQ1OT1 has been reported to be significantly correlated with the prognosis of colon cancer (57–61), the regulatory mechanism of SNHG1 or KCNQ1OT1 underlying the pathogenic differences between colon cancer and rectal cancer has not been well explored. Here, KCNQ1OT1 is linked to rectal cancer.