In a Japanese study, high infiltration of TAMs, especially CD163+ macrophages, in patients with esophageal SCC was associated with worse prognosis and poor response to neoadjuvant treatment (12), whereas Yagi et al. (18) argued for the negative prognostic role of high infiltration of CD163+ and CD204+ macrophages in esophageal cancer in a cohort of 305 patients who had undergone esophageal resection, of whom over 90% had SCC. Here, MSR1 is linked to esophageal cancer.