CD40 and neoplasm: In addition to some chemotherapy drugs, such as nab‐paclitaxel, depleting tumor stroma may also be achieved either by molecules inducing lysis of ECM, such as pegvorhyaluronidase alfa (PEGPH20) and CD40 agonists, or indirectly via drugs targeting CAFs, such as pirfenidone, pasireotide (SOM230), and Hedgehog (HH) pathway inhibitors [12].