In the case of a Notch3 mutation, if any of the 6 Cys is mutated into another amino acid, it leads to a rare neurodegenerative syndrome, called CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) (Papakonstantinou et al., 2019; Vlachakis et al., 2014). Here, NOTCH3 is linked to CADASIL.