POLR3G and neoplasm: Haurie et al. showed that overexpression of POLR3G in IMR90 increased the expression of genes associated with tumor growth and metastasis, including S100A4, RFC2, EZR, and RAC1, and reduced the expression of tumor-suppressing genes, such as PFDN5 and KLF6 (Haurie et al., 2010).