POLR3G and infection: POLR3G plays a role in sensing and limiting infection by intracellular bacteria and DNA viruses, acts as a nuclear and cytosolic DNA sensor involved in innate immune responses, and is also essential for the maintenance of stem cell state (Ablasser et al., 2009; Chiu, Macmillan & Chen, 2009; Lund et al., 2017; Wong et al., 2011).