Activated microglia can mediate neuroinflammation in various neurological disorders via producing proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-4 (IL-4) and interferon-γ (IFN-γ) (Yan et al., 2019; Na, Jung & Kim, 2012). Here, IL1B is linked to nervous system disorder.