Significantly enriched pathways for up-regulated genes were found to include ECM organization and receptor interaction, focal adhesion-PI3K-Akt-mTOR signaling pathway, and integrin signaling pathway, which have well-known associations with pancreatic cancer (Ebrahimi et al., 2017; Topalovski & Brekken, 2016). Here, AKT1 is linked to familial pancreatic carcinoma.