SMAD3 and familial pancreatic carcinoma: Although there are scientific reports on the prognostic values of SMAD3 (Yamazaki et al., 2014) and CTNNB1 (Zhang et al., 2016) in pancreatic cancer, the precise functions of Jun Oncogene (JUN) and TCF-7 in the pathogenesis of pancreatic cancer are still largely unknown and require further understanding and research.