Among the 27 hub proteins, ITGA2 and COL17A1 were found to be associated with unfavorable prognosis for PDAC based on the TCGA Pan-Cancer pancreatic ductal adenocarcinoma dataset in Km-Plotter (P ≤ 0.05 and FDR ≤ 0.05). This evidence concerns the gene COL17A1 and cancer.