Moreover, it is reported that miR-124 expression is reduced in HD patients and can lead to upregulation of neuron-restrictive silencing factor (NRSF) expression, thereby suppressing the expression of brain-derived neurotrophic factors, suggesting that abnormal expression of miR-124 plays a key role in the pathogenesis of HD [129, 151, 152]. The gene discussed is REST; the disease is Huntington disease.