APP and early-onset autosomal dominant Alzheimer disease: Finally we investigated the modulation of intracellular AD markers, by using the antibody 6E10, specific for human Amyloid precursor protein (APP), Aβ oligomers [29], and molecules generated from cleavage of APP by secretases [30], and anti-Tau phosphorylated in Serine 422 [31], a pathological epitope and one of the markers of neurofibrillary degeneration: both are neuropathological hallmarks of Alzheimer's disease.