The results, confirmed in primary human hepatocytes and coronary artery smooth muscle cells, demonstrate for the first time that IL-17 is a potent inducer of C-reactive protein expression via p38 mitogen-activated protein kinase and extracellular regulated protein kinase 1/2-dependent NF-κB and CCAAT/enhancer binding protein β activation and suggest that IL-17 may mediate chronic inflammation, atherosclerosis, and thrombosis [36]. The gene discussed is NFKB1; the disease is atherosclerosis.