RASSF1 and hepatocellular carcinoma: The aim of this study was therefore to test two hypotheses: (i) the amide-type local anesthetics lidocaine, ropivacaine and bupivacaine may exert potential antitumor activity in hepatocellular carcinoma and (ii) the three amide-type local anesthetics may sensitize hepatocellular carcinoma cells to cisplatin-mediated cytotoxicity via upregulation of RASSF1A expression.