Consequently, we established a retrospective single-institutional database including consecutive EGFR-mutant advanced NSCLC patients with synchronous BM or metachronous BM from January 2012 and June 2018, to evaluate the survival of patients grouped by BM status, to explore the prognostic factors of OS, and to analyze potential mechanism of different outcomes based on BM status. Here, EGFR is linked to non-small cell lung carcinoma.