STAT3 and cancer: For instances, curcumin, resveratrol, apigenin, eugenol, and genistein are well-known cancer preventive agents, and some of their analogues have synergic effects targeting multiple pathways, including cyclooxygenase-2 (COX-2), signal transducer and activator of transcription-3 (STAT-3) signaling, and reactive oxidative species (ROS) 10-14.