In addition, gender, age, BMI, serum CEA and CRP level, albumin level, neutrophils and platelet counts, PNI score, NLR, metastasis, stage of NSCLC, surgery, therapy of radiation, application of platinum or TKI, target therapy, chemotherapy, smoking, hyperlipemia, heart failure, and KPS score were also associated with overall mortality (Table 2). The gene discussed is CRP; the disease is familial hyperlipidemia.