Furthermore, gender, age, BMI, serum CEA and CRP level, albumin level, neutrophils and platelet counts, PNI score, NLR, metastasis, stage of NSCLC, surgery, therapy of radiation, application of platinum or TKI, target therapy, chemotherapy, smoking, hyperlipemia, heart failure, and KPS score were correlated with overall mortality. This evidence concerns the gene CRP and heart failure.