As shown in Table 5, the irAEs were categorized on the basis of the organ/system involving skin, endocrine, respiratory system, hepatic system, cardiac system (including premature ventricular beats and myocardial ischemia), gastrointestinal and others irAEs (including fever, fatigue, anemia, thrombocytopenia, albumin reduction, dizziness, hyponatremia, hypochloremia, creatinine increase, uric acid increase, xerophthalmia, pigmentation). The gene discussed is ALB; the disease is Keratoconjunctivitis sicca.