A meta-analysis also showed that adding CDK4/6 inhibitors in endocrine-sensitive (HR 0.55, 95% CI 0.50-0.62) or endocrine-resistant setting (HR 0.51, 95% CI 0.43-0.61) significantly improved the PFS of metastatic hormone receptor-positive, HER2-negative breast cancers regardless of menopausal status and site of metastasis29. The gene discussed is NR4A1; the disease is breast carcinoma.