TNF and Sepsis: The vast array of inflammatory cytokines released during sepsis include proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-12, tissue necrosis factor (TNF)-α, interferon (IFN)-γ, and macrophage migration inhibitory factor (MIF) and anti-inflammatory cytokines, such as IL-10, IL-14, and transforming growth factor (TGF)-β.