The mean IL-6 level was significantly lower in HIV seropositive pregnant women without malaria parasitemia (1.83 ± 0.55), HIV seronegative pregnant women with malaria parasitemia (1.80 ± 0.57) compared with HIV seropositive pregnant women with malaria (2.45 ± 1.05), HIV seronegative pregnant women without malaria parasitemia (2.34 ± 0.90), and nonpregnant HIV seronegative women without malaria (2.17 ± 1.04) (p=0.008). This evidence concerns the gene IL6 and malaria.