Consistent with this, Tip60 (KAT5), which belongs to the MYST acetyltransferase family, was recently reported to contribute to a reduction of H3K4 acetylation in breast cancer and the decrease of Tip60 expression could promote the tumorigenesis of ER-negative tumors (Judes et al., 2017, 2018). This evidence concerns the gene KAT5 and breast cancer.