p300 was demonstrated to bind with DOT1L-c-Myc complex to epigenetically induce epithelial-mesenchymal transition (EMT) regulators in breast cancer progression, which indicated that p300 served as a potential oncogene for the acquisition of aggressive phenotype of breast cancer by promoting EMT and enhances the transformation of CSCs (Cho et al., 2015). The gene discussed is DOT1L; the disease is breast carcinoma.