The subsequent studies of the underlying mechanism found that there are some interactions between the DNA methylation and histone modification, such as MAML2, UHRF1, mdig, and EZH2, which directly or indirectly induce the silencing of tumor suppressor genes in breast cancer cells (Lubecka et al., 2016; Liu X. et al., 2018; Patnaik et al., 2018; Thakur et al., 2018). Here, EZH2 is linked to breast cancer.