p300 was demonstrated to bind with DOT1L-c-Myc complex to epigenetically induce epithelial-mesenchymal transition (EMT) regulators in breast cancer progression, which indicated that p300 served as a potential oncogene for the acquisition of aggressive phenotype of breast cancer by promoting EMT and enhances the transformation of CSCs (Cho et al., 2015). This evidence concerns the gene DOT1L and breast cancer.