A further study has accessed the relationship between the SIRT1, H3k4ac, H3k9ac, and H4k16ac in different subtypes of breast cancer and found that SIRT1 is upregulated in luminal and HER2-enriched subtypes and significant downregulation in TNBC subtype while H3k4ac, H3k9ac, and H4k16ac were significantly reduced in luminal and HER2-enriched subtypes and relatively upregulated in TNBC subtype (Rifai et al., 2018). This evidence concerns the gene ERBB2 and breast cancer.