When their prognostic effects were adjusted for gender, age, and tumor stage, the unfavorable effects of KPNA2 (HRTCGA-HCC = 1.78, HRICGC-HCC = 2.45, p < 0.05; Figures 5C,G), GRB2 (HRTCGA-HCC = 1.67, HRICGC-HCC = 1.97, p < 0.05; Figures 5D,H), and NRAS (HRTCGA-HCC = 1.59, HRICGC-HCC = 2.39, p < 0.05; Figures 5E,I) on HCC OS also existed in both TCGA-HCC and ICGC-HCC datasets, indicating their potential in the predication of HCC prognosis. This evidence concerns the gene KPNA2 and hepatocellular carcinoma.