At protein level, through CPTAC-HCC analysis, KPNA2 (p < 0.001; Figure 6A) and GRB2 (p < 0.001; Figure 6B) were found to be higher expressed in HCC tumors than their normal liver tissues, consistent with their upregulation in HCC tumors at mRNA level. The gene discussed is GRB2; the disease is hepatocellular carcinoma.