Here, we presented the overexpression of GRB2, its positive correlation with cell proliferation marker MKI67, and its unfavorable prognostic roles in HCC, indicating its associations with HCC development and progression, consistent with the tumor-promoting activity of GRB2 in HCC reported in recent studies (Yang et al., 2018; Lv et al., 2020; Sun et al., 2020). Here, GRB2 is linked to hepatocellular carcinoma.