BCR and hepatocellular carcinoma: As shown in Figure 4, besides the overexpression of KPNA2 in HCC tumors, among the seven-KPNA2 positively correlated BCR signaling pathway genes, six genes including GRB2, NRAS, NFKBIE, MAPK3, and NFATC2 were shown to be higher expressed, whereas NFATC2 was lower expressed in the HCC tumors than the normal liver tissues (p < 0.05) in both TCGA-HCC dataset (Figure 4A) and ICGC-HCC dataset (Figure 4B).