Through univariable Cox regression analysis (Figures 5A,B), besides the unfavorable prognostic effects of KPNA2 (HRTCGA-HCC = 1.823, HRICGC-HCC = 2.234, p < 0.05), two of its positively correlated BCR signaling pathway genes (NRAS: HRTCGA-HCC = 1.775, HRICGC-HCC = 2.664, p < 0.05; GRB2: HRTCGA-HCC = 1.901, HRICGC-HCC = 2.470, p < 0.05) and one of its negatively correlated genes (BLNK: HRTCGA-HCC = 0.771, HRICGC-HCC = 0.786, p < 0.05) were shown to be prognostic factors both in the TCGA-HCC patients and ICGC-HCC patients. Here, GRB2 is linked to hepatocellular carcinoma.