Moreover, previous studies have indicated that RBPs play a significant role in the initiation and progression of PCa; for instance, TDRD1, an ERG target gene, can promote the occurrence and development of PCa (Xiao et al., 2016), and PCBP1 could increase the tumorigenicity and metastasis of PCa by inhibiting the expression of mitogen-activated protein kinase 1 (Zhang et al., 2018). The gene discussed is MAP2K1; the disease is posterior cortical atrophy.