The genetic over-expression of SIRT1 or its activation by resveratrol treatment protects against HFD-induced hepatosteatosis and glucose intolerance (Rodgers and Puigserver, 2007; Pfluger et al., 2008) as well as alcoholic diet-induced liver injury and fibrosis (Ajmo et al., 2008; Ramirez et al., 2017). The gene discussed is SIRT1; the disease is Glucose intolerance.