Similarly, the expression of the glucagon-like peptide-1 receptor (GLP1R), involved in enhanced GSIS upon GLP-1 peptide binding (Muller et al., 2019), is decreased in pancreatic islets of T2D patients and hyperglycemic rats (Xu et al., 2007; Shu et al., 2009; Taneera et al., 2012). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.