While insulin-secreting β-cells and glucagon-secreting α-cells have different physiological functions, a study revealed that human α, β, and exocrine cells share similar profiles of histone methylation of H3K4me3 and H3K27me3, suggesting an epigenomic plasticity of islet cells and their reprogrammable potentials to treat diabetes (Bramswig et al., 2013). The gene discussed is INS; the disease is diabetes mellitus.