Among HATs, the transcriptional coactivator p300 is activated in mouse models of obesity and T2D, leading to post-translational hyperacetylation of ChREBP, involved in the transcriptional activation of lipogenic (e.g., Acc, Fas) and glycolytic (e.g., Pepck, G6Pase) genes (Bricambert et al., 2010). Here, ACACA is linked to type 2 diabetes mellitus.