KDM4B and Hepatic steatosis: Similarly, the H3K9 di- and tri-demethylase JMJD2B (KDM4B), involved in establishing the H3K9me activation mark, is upregulated in livers of diet-induced obese mice, resulting in increased hepatic PPARγ2 expression and induction of hepatic steatosis (Kim et al., 2018).