G9a (aP2-Cre; Ehmt2flox/flox) and Ehmt1 (Adipoq-Cre; Ehmt1flox/flox) knockout mice develop increased adiposity (Ohno et al., 2013; Wang L. et al., 2013), while adipose tissue-specific Ehmt1 knockout mice also present with reduced BAT thermogenesis and insulin resistance (Ohno et al., 2013). This evidence concerns the gene EHMT1 and Insulin resistance.