EHMT1 and obesity due to melanocortin 4 receptor deficiency: Interestingly, patients with Kleefstra syndrome can have a 9q34 chromosomal deletion containing the EHMT1 gene and display childhood obesity, thus suggesting a plausible role for EHMT1 in obesity development (Cormier-Daire et al., 2003; Willemsen et al., 2012).