NR1H4 and Cirrhosis: Since the degree of hepatic fibrosis is an indicator of morbidity and mortality of liver diseases including NAFLD (Dulai et al., 2017), a DNA methylation study conducted with liver samples with NAFLD-related cirrhosis has identified genes enriched in ligand-activated nuclear receptor signaling pathways, involving farnesoid X receptor (FXR), liver X receptor (LXR), and retinoid X receptor (RXR), that play roles in fatty liver disease (Tanaka et al., 2017; Gerhard et al., 2018).