ADCY5 and type 2 diabetes mellitus: Moreover, in a separate study, genome-wide DNA methylation quantitative trait locus (mQTL) analysis in human pancreatic islets (Olsson et al., 2014) has identified over 67,000 CpG-SNP pairs, with several mQTLs associated with differential expression of T2D- and insulin secretion-related genes (e.g., ADCY5, KCNJ11, INS, PDX1 and GRB10) in human islets.