In particular, a study comparing young and aged female mice showed that 40% CR delays the epigenetic aging of hepatic lipid metabolism by inducing hypermethylation and down-regulation of key enzymes involved in hepatic insulin resistance (e.g., Srebp1), lipid synthesis (e.g., Acly, Mel, Aacs2, Acac, Pklr, Gpam) and lipid elongation (e.g., Elov15, Elov16). Here, SREBF1 is linked to Insulin resistance.