Hypomethylation of a CpG site within or proximal to the activating transcription factor (ATF)-binding motif of hepatic genes accounts for increased expression of these genes involved in glycolysis (PFKL), DNL (ACACA, FASN), and insulin signaling (PRKCE) in obese and T2D patients (Kirchner et al., 2016). The gene discussed is ACACA; the disease is type 2 diabetes mellitus.