In obesity, adipose SIRT2 expression is suppressed by adipose hypoxia-induced cellular hypoxia-inducible factor 1-α (HIF1α), which prevents SIRT2-mediated post-translational deacetylation and activation of PGC-1α and its FAO transcriptional gene program (Zhang X. et al., 2010; Krishnan et al., 2012). The gene discussed is SIRT2; the disease is obesity due to melanocortin 4 receptor deficiency.