In addition, hypomethylation of CpG sites within TGFβ1, Collagen 1A1, and PDGFα as well as hypermethylation of CpG sites within PPARα and PPARδ are frequently associated with the increased risk of fibrosis in NAFLD patients (Zeybel et al., 2015; Abderrahmani et al., 2018). This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.