ACACA and type 2 diabetes mellitus: On the other hand, the H3K9 demethylase, JMJD1C (KDM3), a candidate gene associated with T2D and plasma TG levels (Chasman et al., 2009; Teslovich et al., 2010; Zhang H. et al., 2016), regulates hepatic lipogenic gene expression (e.g., FAS, ACC, SREBF1) by demethylating the H3K9me2/me3 transcriptional repressor marks and leading to increased chromatin accessibility (Viscarra et al., 2020).