FUS and amyotrophic lateral sclerosis: For example, mutations in the genes encoding the RBPs Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) have been linked to the pathogenesis of amyotrophic lateral sclerosis, and the proteins were depleted from the nucleus and aggregated in the cytoplasm in affected neurons (Brinegar and Cooper, 2016).