AHR and cancer: In addition, AHR was reported to be involved in a multitude of normal physiological function as well as pathological processes such as cell circle regulation, immune response, apoptosis, oxidative stress, cancer, tumorigenesis and CNS metabolism (Nebert et al., 2000; Marlowe and Puga, 2005; Puga et al., 2009; Juricek and Coumoul, 2018).