However, overexpression of NNMT was remarkably correlated with better prognosis in HER2-negative GC patients who received 5-fluorouracil (5-FU)-based adjuvant treatment (Table 1), suggesting that NNMT might be a potential indicator of successful 5-FU therapy in HER2-negative GC patients. The gene discussed is ERBB2; the disease is gastric cancer.