Consistently, NNMT silencing is linked with apoptosis of breast cancer cells (Zhang et al., 2014), as well as the decreased tumorigenicity of non-small cell lung cancer cells (Sartini et al., 2015), oral carcinoma cells (Pozzi et al., 2013), and glioblastoma cells (Palanichamy et al., 2017). Here, NNMT is linked to breast cancer.