In addition, NNMT overexpression was found to be associated with increased tumorigenesis of colorectal cancer (Xie et al., 2014), bladder cancer (Wu et al., 2008), squamous cell carcinoma (Hah et al., 2019), and clear cell renal cell carcinoma (Tang et al., 2011). This evidence concerns the gene NNMT and urinary bladder carcinoma.