So far, Seta et al. found that overexpression of NNMT was associated with upregulation of an anti-apoptotic protein survivin-ΔEx3 in OSCC cell line (HSC-2) (Seta et al., 2019), and Akar et al. reported that NNMT overexpression was correlated with aberrant p53 and phospho-Akt expression in high-grade endometrial cancer (Akar et al., 2019). This evidence concerns the gene NNMT and endometrial cancer.