BRCA1 and ovarian carcinoma: Interestingly, BRCA1 depletion-induced NNMT upregulation was shown to promote metabolic reprogramming of ovarian cancer cells, which sensitized ovarian cancer cells to agents that inhibit mitochondrial metabolism (VLX600 and tigecycline) and to agents that inhibit glucose import (WZB117) (Kanakkanthara et al., 2019).