Consistently, NNMT silencing is linked with apoptosis of breast cancer cells (Zhang et al., 2014), as well as the decreased tumorigenicity of non-small cell lung cancer cells (Sartini et al., 2015), oral carcinoma cells (Pozzi et al., 2013), and glioblastoma cells (Palanichamy et al., 2017). This evidence concerns the gene NNMT and breast carcinoma.