UPF1 regulates tumor progression via diverse mechanisms across different kinds of cancers, including CRC (Bordonaro and Lazarova, 2019), hepatocellular carcinoma (Chang et al., 2016; Zhang et al., 2017), pancreatic adenosquamous carcinoma (Liu et al., 2014), glioblastoma (Shao et al., 2019), and endometrial carcinoma (Xing et al., 2020). The gene discussed is UPF1; the disease is cancer.