UPF1 regulates tumor progression via diverse mechanisms across different kinds of cancers, including CRC (Bordonaro and Lazarova, 2019), hepatocellular carcinoma (Chang et al., 2016; Zhang et al., 2017), pancreatic adenosquamous carcinoma (Liu et al., 2014), glioblastoma (Shao et al., 2019), and endometrial carcinoma (Xing et al., 2020). This evidence concerns the gene UPF1 and hepatocellular carcinoma.