TP53 and Familial prostate cancer: The other countries (United States: 9.9%, and Germany: 8.9%) showed an intermediate range of mutational events in TP53. Moreover, the distributions of six different hotspot variants (Tyr163Cys, Cys176Trp, Met237Ile, Cys238Phe, Arg248Gln, and Arg273Cys) of TP53 with the highest frequency in prostate cancer for different countries are shown (Figure 5B).