The SRC downstream signal pathways, such as protein tyrosine phosphatase α (PTPα), SH-containing phosphatases SHP1/SHP2, and nuclear factor-kappa B (NF-κB) pathway indicate a vital role of SRC in occurrence and development of CRC (Aleshin and Finn, 2010; Brady et al., 2011). The gene discussed is NFKB1; the disease is colorectal carcinoma.