Moreover, in terms of PIK3R3, RNASE7, and TNFRSF12A, similar results have been obtained in other researches, indicating that these genes might be engaged in immune-related pathways and promote tumor progression (Scola et al., 2012; Wang et al., 2015; Eichler et al., 2016; Yang et al., 2018; Sun and Feng, 2020). Here, PIK3R3 is linked to neoplasm.