TMPRSS2 and prostate carcinoma: In certain studies, according to the immunohistochemical analysis of clinical specimens, TMPRSS2 has the highest expression in the apex of the prostate, the secretory epithelium of prostate cancer, and the glandular cavity, indicating that TMPRSS2 is a secreted protease that is highly expressed in prostate cancer and prostate cancer, making it a potential target for the treatment and diagnosis of cancer (Afar et al., 2001).