More specifically, TMPRSS2 can cleave the SARS-COV-2 spike protein, facilitating viral entry and activation (Strope et al., 2020), and TMPRSS2-expressing cell lines are highly susceptible to SARS-COV, Middle East respiratory syndrome-coronavirus (MERS-COV), and SARS-COV-2 (Matsuyama et al., 2020), which prompted us to explore the association between TMPRSS2 and SARS-COV-2, especially in PRAD patients. The gene discussed is TMPRSS2; the disease is prostate adenocarcinoma.