Further studies on immune cell type marker PRAD (Table 1) showed that the expression level of TMPRSS2 mRNA was correlated with B-cells (CD19, CD27, and CD38), and CD8+ in PRAD T-cells (CD8A and CD8B), neutrophil granulocytes (FCGR3B, SIGLEC5, and S100A12), macrophages (CD84 and CD163), Th1 (STAT4 and STAT1), Treg (STAT5B and TGFB1), and T-cell failure (PDCD1, CTLA4, LAG3, and GZMB) were significantly correlated, suggesting that these results strongly confirm the close correlation between TMPRSS2 and immune infiltration of PRAD. The gene discussed is SIGLEC5; the disease is prostate adenocarcinoma.