The study indicated that SEC16 homolog B (SEC16B), transmembrane protein 18 (TMEM18), glucosamine-6-phosphate deaminase 2 (GNPDA2), brain-derived neurotrophic factor (BDNF), fas apoptotic inhibitory molecule 2 (FAIM2), and melanocortin 4 receptor (MC4R) loci are not only associated with BMI in European ancestry individuals but also with obesity in Japanese ancestry individuals. The gene discussed is SEC16B; the disease is obesity due to melanocortin 4 receptor deficiency.