Pancreatic polypeptide Y receptor Y4 (PPYR1) located under this CNV area appears to be a plausible gene eventually related to obesity, and Shebanits et al. (2018) have also found similar findings in a Swedish cohort which suggested an association of PPYR1 (NPY4R) with WC in women. This evidence concerns the gene NPY4R and obesity due to melanocortin 4 receptor deficiency.