It should be pointed out that FTO variants have not been related to obesity and being overweight only in European and Asian but also in African (Monda et al., 2013), Hispanic (Villalobos-Comparán et al., 2008; Dong et al., 2011), and Native American populations (Rong et al., 2009), in both adults and children (Dina et al., 2007; Frayling et al., 2007), implicating the global impact of FTO polymorphisms on obesity. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.