PROX1 and obesity due to melanocortin 4 receptor deficiency: Kim et al. (2013) identified the prospero homeobox 1 (PROX1) locus in a GWAS for BMI in a cohort from Mongolia and replicated it in a cohort from Korea. However, the associations only reached suggestive significance with p < 10–7. The limited statistical power was likely attributed to the relatively small sample size (n = 1301). Albeit not statistically significant at the genome-wide level, the study also suggested protein tyrosine phosphatase receptor type D (PPTRD) and reelin (RELN) to be potential candidate genes that may have a role in the development of obesity.