In the cohort from the GEPIA database, the expression of NOX4, COL8A1, and CHST1 in gastric cancer tissues was higher than that in normal tissues, and the expression levels of NOX4 (F = 5.67 and P = 0.0008) and COL8A1 (F = 6.49 and P = 0.0003) differed across the four pathological stages (Figures 11A,B). The gene discussed is NOX4; the disease is gastric cancer.