VAV2 and neoplasm: Many genes in these chromosome regions, such like ERLIN2 (amp 8p11.23) (Wang et al., 2012), VAV2 (del 9q34.2) (Tan et al., 2017), ADAMTS6 (del 5q12.3) (Xie et al., 2016)and NCS1 (del 9q34.11) (Moore et al., 2017), are known to be related with tumor invasion and metastasis.