In the last decade, the role of mitochondria in metabolic pathways and cell metabolism became apparent and may become a therapeutic target against cancer (Porporato et al., 2018), and play driver roles in some cancer types (Yuan et al., 2020) including GBM, such as the IDH1-mutated GBM cells that are full of mitochondria (Navis et al., 2013) and the importance of mitochondria in relation to altered energy metabolism (Khurshed et al., 2017). The gene discussed is IDH1; the disease is glioblastoma.