The Collaborative Group of the Americas on Inherited Gastrointestinal Cancer recently published a recommendation regarding gene panel testing in hereditary CRC or polyposis, and they recommend that multigene testing as a minimum includes the MMR-genes, EPCAM, APC, MUTYH, BMPR1A, SMAD4, PTEN and STK11 (Heald et al., 2020). This evidence concerns the gene SMAD4 and colorectal carcinoma.