RPS20 and colorectal carcinoma: Nieminen et al. (2014) did not provide detailed data on age at onset, but the mean age at onset of CRC were 52.3 years. Due to the scarcity of families with RPS20 variants, data on genotype-phenotype correlations are premature, but if the c.98A>T variant turns out to be pathogenic it will not only confirm the role of RPS20 in hereditary CRC, but it will also expand the phenotypic spectrum of RPS20 related cancer significantly. Due to the very high probability of RPS20 truly being a new cancer gene, we recommend inclusion of RPS20 in cancer gene panels.