Chinese scientists longitudinally studied the relationship of BDNF Val66Met (Fan et al., 2017), Preproghrelin Leu72Met (Su et al., 2017), oestrogen receptor alpha gene (ESR1) rs9340799 (Feng et al., 2017), adiponectin rs1501299 (Wang et al., 2015), tumor necrosis factor receptor-II (TNF-RII) rs1061622 (Memon et al., 2018) and insertion/deletion polymorphism at angiotensin-converting enzyme gene (ACE I/D) (Fan et al., 2018)with depression in adolescents after the 2008 Wenchuan earthquake. This evidence concerns the gene ESR1 and major depressive disorder.