EHD3 and major depressive disorder: Only a few scientists have reported gene loci related to gender differences in depression: SNP rs6602398, presented in interleukin receptor 2A gene (IL2RA), was significantly associated with males MDD (Powers et al., 2016); 2 SNPs rs619002 and rs644926, presented in the EH-domain containing 3 (EHD3) gene, were associated with female MDD (Wang et al., 2014).