RAPTOR facilitated proliferation, migration, and cell cycle progression by promoting the Mtorc1 pathway and transcriptional activation of both URB1 and CCNA2, and CCNA2 can act as a novel biomarker via regulating growth and apoptosis of CRC (Gan et al., 2018; Wang et al., 2020). The gene discussed is URB1; the disease is colorectal carcinoma.