PLOD1 and Hypergonadotropic hypogonadism: Hypergonadotropic hypogonadism (HH; also termed primary hypogonadism) in men is defined by reduced production of either sperm, testosterone, or both, accompanied by elevated levels of the pituitary gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH; Viswanathan and Eugster, 2011; Basaria, 2014).