Among the 12 hub genes, kinesin family member 11 (KIF11), TPX2 microtubule nucleation factor (TPX2), kinesin family member 20A (KIF20A), and cyclin B2 (CCNB2) were found to be independent prognostic markers of HBV-related HCC. This evidence concerns the gene TPX2 and hepatocellular carcinoma.