To deternmine whether KIF11, TPX2, KIF20A, and CCNB2 are specific to HBV-induced HCC comparing with HCV-induced HCC, HCV-related HCC (GSE69715) and HBV-related HCC (GSE94660) datasets were used to analyze the relative expression levels (i.e., fold change) of these 4 genes in HCC and normal tissue samples. This evidence concerns the gene KIF11 and hepatocellular carcinoma.