TPX2 and hepatocellular carcinoma: As indicated in Table 1, univariate Cox regression analysis showed that all the 12 hub genes were high-risk genes (hazard ratio >1, p-value < 0.05); however, multivariate Cox regression analysis suggested that only KIF11, TPX2, KIF20A, and CCNB2 were independent prognostic genes in case of patients with HCC (hazard ratio >1, p-value < 0.05).