Among the 12 hub genes, kinesin family member 11 (KIF11), TPX2 microtubule nucleation factor (TPX2), kinesin family member 20A (KIF20A), and cyclin B2 (CCNB2) were found to be independent prognostic markers of HBV-related HCC. The gene discussed is CCNB2; the disease is hepatocellular carcinoma.