TP53 and cancer: Upregulated genes were enriched in more pathways, in particular, in the BIOCARTA pathway, “role of mitochondria in apoptotic signaling” (p value, 1.9E-2), and in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (Kanehisa and Goto, 2000) such as “p53 signaling” (p value, 9.4E-2), “transcriptional misregulation in cancer” (p, 4.6E-4), “chromatin organization” (R-HSA-3214858; p value, 1.9E-15), “RMTs methylate histone arginines” (p value, 1.2E-15), “HDACs deacetylate histones” (p value 1.8E-14), and “condensation of prophase chromosomes” (p value, 2.8E-14).