NPHS2 and focal segmental glomerulosclerosis: Establishing a distinction between pathogenic and benign associations with R229Q is important, but difficult in clinical practice because the phenotype of NPHS2-related SRNS/FSGS is observed also in patients without NPHS2 mutations (Sadowski et al., 2015) and the p.R229Q variant is common in the European, South Asian, African, and Latino-American population (Mikó et al., 2018).