GSTM1 and gastric adenocarcinoma: Cumulative evidence has shown that genetic factors, such as Glutathione S-transferase M1 (GSTM1)-null phenotypes and variants in the E-cadherin (CDH1), interleukin-17 (IL-17) and interleukin-10 (IL-10) contribute to the development of STAD (Meng et al., 2014; Long et al., 2015; Alvarez-Escola et al., 2019; Gao et al., 2019).