TTN and cancer: Based on the RefSeq gene annotation, we identified TTN, MUC4, FLG2, MUC17, OR2T4, ZNF850, FAM186A, ALMS1, FAM47C, and ATM as the top ten mutated genes (Figure 1D), however, only ATM was previously reported to be implicated in cancer (Kim et al., 2014; Chen et al., 2015; Feng et al., 2015).